If you meant Valencia to Granada then it is possible to get there in one day. It's a long drive though, about 520km and depending on mph I would say it would take about 5 1/2 - 6 hrs to get there. This is without stopping so you would have to add extra time for breaks. Petrol will cost about 50 euros and tolls around 10 euros. It's mostly motorway and fairly straight forward.
Personally if it was just a matter of getting from a to b I would set off really early about 3-4 am to avoid all the traffic and lorries that can sometimes slow you down
Click on this link and type in departure Spain then Valencia central and destination Spain Granada central
http://www.viamichelin.co.uk/viamichelin…
It will give you directions and a map
Safe journey