The answer is YES!
FDA Approved Uses: Major Depression, Obsessive-Compulsive Disorder (adults and children), Panic Disorder, Post Traumatic Stress Disorder, Premenstrual Dysphoric Disorder, Social Anxiety Disorder.
Off-Label Uses: Fibromyalgia, Arthritis, Chronic Fatigue, Multiple Sclerosis, Bipolar Depression, Lupus, Headaches, Irritable Bowel Syndrome (IBS), ADD/ADHD, Eating Disorders, Autistic Spectrum Disorders.
Zoloft's Dosage and How to Take Zoloft: I'm just sticking with adults. Zoloft (sertraline hydrochloride) is approved for use by kids with OCD, but it's too tricky for me to deal with.
Depression and OCD - 50mg, once a day, usually in the morning. That's it. No titration. You can try taking more, as Zoloft (sertraline hydrochloride) is rated up to 200mg a day, but Pfizer's data don't prove it to be effective at more than 50mg a day. In the real world people do get plenty of benefit from taking more than 50mg a day, but give it a month before increasing the dosage. After that increase it by 25-50mg a day each week, as required, until it works or you give up. You should know by six weeks after starting if it's going to do anything or not.
Panic, PTSD and Anxiety disorders - 25mg, once a day, usually in the morning. After at least a week you may increase it to 50mg a day. That's it, just like depression & OCD. You can try taking more, but as above Pfizer states it's not worth it.
PMDD - start at 50mg a day. You'll have to work it out with your OB-GYN as to which days in your cycle will work best. If that doesn't work, up it by another 50mg next month. Then try other days in your cycle. Then try another 50mg a day. There's a bunch of fine-tuning required here.
Really, folks, don't go increasing the Zoloft (sertraline hydrochloride) every week until you've given it 4-6 weeks. You're risking a nasty bout of discontinuation syndrome for something that may not work for you at all. You'll know if it's going to work after a month. If it doesn't do anything at all at the initial dosage after six weeks, give up and move on. If it does something, just not enough, you can discuss a higher dosage with your doctor.
Days to Reach a Steady State: About a week.
When you're fully saturated with the medication and less prone to peaks and valleys of effects. You still might have peaks of effect after taking many meds, but with a lot of the meds you'll have fewer valleys after this point. In theory anyway.
How Long Zoloft Takes to Work: Like all SSRIs anywhere from a couple days to over a month. If you don't feel any positive benefit after six weeks, then you should talk to your doctor about either another SSRI or trying a med that hits another neurotransmitter.
Source(s):
www.crazymeds.org