What is the time that resistance will happen to AZT (Zidovudine)?

Answer 1

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Several published studies indicate that AZT-resistant HIV strains are most likely isolated from persons with more advanced HIV illness, with lower absolute CD4 cell counts, or with a longer time on AZT treatment.[3,10,11,12] High-level resistance to AZT has been detected as early as ten months after starting AZT therapy. On the other hand, a number of individuals do not seem to carry AZT-resistant HIV even after taking the drug for several years. During the Amsterdam conference, Douglas Mayers tabulated the results of susceptibility studies performed on HIV isolates from 60 individuals receiving AZT. After one year of AZT therapy only about one-fifth of the isolates manifested high-level AZT resistance. After two or more years, about half of the isolates showed such resistance.

Source(s):

http://www.aegis.com/pubs/step/1992/STEP…

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Asker's Comment:

great!

Answer 2

I don't think resistance to AZT (Zidovudine) has been medically proven yet. If I am incorrect, please let me know.