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OK, here's how I did mine.
Assuming your car has a carburetor, either buy new main jets or drill out your old ones 25-30% larger. Advance the timing a few degrees. (you will have to experiment, my ford 5.0 was able to take 8 degrees more advance) Install a good quality fuel filter at the carb.
Install a new performance fuel pump that is designed for alcohol, and replace all your rubber fuel lines with ones designed for alcohol. (e85 will cause some types of rubber to disintegrate)
Your car will not start with e85 in cold weather with this setup. You can either switch back to gasoline with a spare carb & readjust the timing in the winter, or design a fuel heater in the upper radiator hose and something to spray gasoline into the top of the carb for starting. (if you live in a very warm climate this may not be an issue)
Expect around a 15-20% loss in fuel mileage, and a noticeable increase in power.
I installed high compression pistons & got some fuel mileage back, but it now has too much compression to run on pump gas, which isn't an issue for me since I did the changeover for performance & it is only driven in good weather.
I even run my lawnmower on e85, just open the needle valve a couple of turns & it runs fine.
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- This person was the only one to actually give me an answer and would like to thank him.