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The best OTC therapy for acne is a combination of products. Go for a facial wash (preferably in gel form) that contains Salicylic Acid 2%(like L'oreal Pure Zone gel face wash, or Olay Clarity Daily Face Wash). Use a facial scrub (also containing Salicylic Acid 2%) 2-3 times a week, or daily if your acne is severe (Olay Clarity Daily Facial Scrub and St Ives Medicated Scrub for Acne-prone Skin are good bets). Then treat blemishes with a spot medication containing Benzoil Peroxide 10% (Clearasil Ultra Blemish Treatment is a good alternative). If your skin tends to dry out when using any of these products, then an oil-free moisturizer formulated for acne-prone skin is in order (L'oreal Pure Zone Oil-free Moisturizer is the best one I have use to date). This regimen of combining products containing Salicylic Acid with others containing Benzoil Peroxide is the principle behind the much-advertised Proactiv Solution (developed by dermatologists Rodan & Fields). You may also use the Proactiv Solution regimen if you can afford it (it's somewhat costly; about $50:00 for a month's supply; you have to buy direct from the manufacturers because it's not sold in pharmacies).
Source(s):
I'm a Registered Nurse.
Personal experience with teen and adult acne.